Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549...

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Autores principales: Rosselli, Sergio, Bruno, Maurizio, Raimondo, Francesco Maria, Spadaro, Vivienne, Varol, Mehmet, Koparal, Ayşe Tansu, Maggio, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268150/
https://www.ncbi.nlm.nih.gov/pubmed/22777187
http://dx.doi.org/10.3390/molecules17078186
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author Rosselli, Sergio
Bruno, Maurizio
Raimondo, Francesco Maria
Spadaro, Vivienne
Varol, Mehmet
Koparal, Ayşe Tansu
Maggio, Antonella
author_facet Rosselli, Sergio
Bruno, Maurizio
Raimondo, Francesco Maria
Spadaro, Vivienne
Varol, Mehmet
Koparal, Ayşe Tansu
Maggio, Antonella
author_sort Rosselli, Sergio
collection PubMed
description A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.
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spelling pubmed-62681502018-12-12 Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum Rosselli, Sergio Bruno, Maurizio Raimondo, Francesco Maria Spadaro, Vivienne Varol, Mehmet Koparal, Ayşe Tansu Maggio, Antonella Molecules Article A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects. MDPI 2012-07-09 /pmc/articles/PMC6268150/ /pubmed/22777187 http://dx.doi.org/10.3390/molecules17078186 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rosselli, Sergio
Bruno, Maurizio
Raimondo, Francesco Maria
Spadaro, Vivienne
Varol, Mehmet
Koparal, Ayşe Tansu
Maggio, Antonella
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title_full Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title_fullStr Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title_full_unstemmed Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title_short Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
title_sort cytotoxic effect of eudesmanolides isolated from flowers of tanacetum vulgare ssp. siculum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268150/
https://www.ncbi.nlm.nih.gov/pubmed/22777187
http://dx.doi.org/10.3390/molecules17078186
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