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Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage

The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) a...

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Autores principales: Grace-Lynn, Chong, Chen, Yeng, Latha, Lachimanan Yoga, Kanwar, Jagat R., Jothy, Subramanion L., Vijayarathna, Soundararajan, Sasidharan, Sreenivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268155/
https://www.ncbi.nlm.nih.gov/pubmed/23178309
http://dx.doi.org/10.3390/molecules171213937
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author Grace-Lynn, Chong
Chen, Yeng
Latha, Lachimanan Yoga
Kanwar, Jagat R.
Jothy, Subramanion L.
Vijayarathna, Soundararajan
Sasidharan, Sreenivasan
author_facet Grace-Lynn, Chong
Chen, Yeng
Latha, Lachimanan Yoga
Kanwar, Jagat R.
Jothy, Subramanion L.
Vijayarathna, Soundararajan
Sasidharan, Sreenivasan
author_sort Grace-Lynn, Chong
collection PubMed
description The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity.
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spelling pubmed-62681552018-12-14 Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage Grace-Lynn, Chong Chen, Yeng Latha, Lachimanan Yoga Kanwar, Jagat R. Jothy, Subramanion L. Vijayarathna, Soundararajan Sasidharan, Sreenivasan Molecules Article The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity. MDPI 2012-11-23 /pmc/articles/PMC6268155/ /pubmed/23178309 http://dx.doi.org/10.3390/molecules171213937 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Grace-Lynn, Chong
Chen, Yeng
Latha, Lachimanan Yoga
Kanwar, Jagat R.
Jothy, Subramanion L.
Vijayarathna, Soundararajan
Sasidharan, Sreenivasan
Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title_full Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title_fullStr Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title_full_unstemmed Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title_short Evaluation of the Hepatoprotective Effects of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage
title_sort evaluation of the hepatoprotective effects of lantadene a, a pentacyclic triterpenoid of lantana plants against acetaminophen-induced liver damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268155/
https://www.ncbi.nlm.nih.gov/pubmed/23178309
http://dx.doi.org/10.3390/molecules171213937
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