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Total Synthesis of Flocoumafen via Knoevenagel Condensation and Intramolecular Ring Cyclization: General Access to Natural Product

The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction...

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Detalles Bibliográficos
Autores principales:	Jung, Jae-Chul, Lim, Eunyoung, Lee, Yongnam, Min, Dongguk, Ricci, Jeremy, Park, Oee-Sook, Jung, Mankil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268178/ https://www.ncbi.nlm.nih.gov/pubmed/22354187 http://dx.doi.org/10.3390/molecules17022091

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