Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT(1A) Serotonin Receptors

A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT(1A) receptors. The influence of arylpiperazine moiety and benzo[b]thiophene ring substitutions on...

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Detalles Bibliográficos
Autores principales: Pessoa-Mahana, Hernán, Recabarren-Gajardo, Gonzalo, Temer, Jenny Fiedler, Zapata-Torres, Gerald, Pessoa-Mahana, C. David, Barría, Claudio Saitz, Araya-Maturana, Ramiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268179/
https://www.ncbi.nlm.nih.gov/pubmed/22306829
http://dx.doi.org/10.3390/molecules17021388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268179/
https://www.ncbi.nlm.nih.gov/pubmed/22306829
http://dx.doi.org/10.3390/molecules17021388

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