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Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this met...

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Detalles Bibliográficos
Autores principales:	Zhou, Shouxin, Tian, Chao, Li, Chao, Guo, Ying, Wang, Xiaowei, Liu, Junyi, Zhang, Zhili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268183/ https://www.ncbi.nlm.nih.gov/pubmed/22576230 http://dx.doi.org/10.3390/molecules17055604

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