Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra

From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B(1) (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodico...

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Autores principales: Wu, Haifeng, Hu, Xiaoru, Zhang, Xiaopo, Chen, Shilin, Yang, Junshan, Xu, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268185/
https://www.ncbi.nlm.nih.gov/pubmed/22628042
http://dx.doi.org/10.3390/molecules17055212
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author Wu, Haifeng
Hu, Xiaoru
Zhang, Xiaopo
Chen, Shilin
Yang, Junshan
Xu, Xudong
author_facet Wu, Haifeng
Hu, Xiaoru
Zhang, Xiaopo
Chen, Shilin
Yang, Junshan
Xu, Xudong
author_sort Wu, Haifeng
collection PubMed
description From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B(1) (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (5–7), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC(50) value of 2.53 and 1.85 µM, respectively.
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spelling pubmed-62681852018-12-20 Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra Wu, Haifeng Hu, Xiaoru Zhang, Xiaopo Chen, Shilin Yang, Junshan Xu, Xudong Molecules Article From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B(1) (2), 5-O-caffeoylshikimic acid (3), (–)-(7S, 8R)-dihydrodehydro-diconiferyl alcohol (4), (–)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-â-D-glucopyranoside (5–7), and (–)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC(50) value of 2.53 and 1.85 µM, respectively. MDPI 2012-05-04 /pmc/articles/PMC6268185/ /pubmed/22628042 http://dx.doi.org/10.3390/molecules17055212 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Haifeng
Hu, Xiaoru
Zhang, Xiaopo
Chen, Shilin
Yang, Junshan
Xu, Xudong
Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title_full Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title_fullStr Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title_full_unstemmed Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title_short Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra
title_sort benzyl 2-β-glucopyranosyloxybenzoate, a new phenolic acid glycoside from sarcandra glabra
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268185/
https://www.ncbi.nlm.nih.gov/pubmed/22628042
http://dx.doi.org/10.3390/molecules17055212
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