Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

Cystine-knot peptides display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues that form three disulfide bonds, resulting in a notably rigid structural core. Since they highly tolerate either rational or combinatorial changes in their...

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Detalles Bibliográficos
Autores principales: Reinwarth, Michael, Nasu, Daichi, Kolmar, Harald, Avrutina, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268209/
https://www.ncbi.nlm.nih.gov/pubmed/23095896
http://dx.doi.org/10.3390/molecules171112533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268209/
https://www.ncbi.nlm.nih.gov/pubmed/23095896
http://dx.doi.org/10.3390/molecules171112533

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