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Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

Cystine-knot peptides display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues that form three disulfide bonds, resulting in a notably rigid structural core. Since they highly tolerate either rational or combinatorial changes in their...

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Detalles Bibliográficos
Autores principales:	Reinwarth, Michael, Nasu, Daichi, Kolmar, Harald, Avrutina, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268209/ https://www.ncbi.nlm.nih.gov/pubmed/23095896 http://dx.doi.org/10.3390/molecules171112533

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