Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and...

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Autores principales: Edziri, Hayet, Mastouri, Maha, Mahjoub, Mohamed Ali, Mighri, Zine, Mahjoub, Aouni, Verschaeve, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268215/
https://www.ncbi.nlm.nih.gov/pubmed/22695233
http://dx.doi.org/10.3390/molecules17067284
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author Edziri, Hayet
Mastouri, Maha
Mahjoub, Mohamed Ali
Mighri, Zine
Mahjoub, Aouni
Verschaeve, Luc
author_facet Edziri, Hayet
Mastouri, Maha
Mahjoub, Mohamed Ali
Mighri, Zine
Mahjoub, Aouni
Verschaeve, Luc
author_sort Edziri, Hayet
collection PubMed
description We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
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spelling pubmed-62682152018-12-12 Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers Edziri, Hayet Mastouri, Maha Mahjoub, Mohamed Ali Mighri, Zine Mahjoub, Aouni Verschaeve, Luc Molecules Article We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. MDPI 2012-06-13 /pmc/articles/PMC6268215/ /pubmed/22695233 http://dx.doi.org/10.3390/molecules17067284 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Edziri, Hayet
Mastouri, Maha
Mahjoub, Mohamed Ali
Mighri, Zine
Mahjoub, Aouni
Verschaeve, Luc
Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title_full Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title_fullStr Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title_full_unstemmed Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title_short Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
title_sort antibacterial, antifungal and cytotoxic activities of two flavonoids from retama raetam flowers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268215/
https://www.ncbi.nlm.nih.gov/pubmed/22695233
http://dx.doi.org/10.3390/molecules17067284
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