A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), w...

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Detalles Bibliográficos
Autores principales: Yang, Chung-Ping, Huang, Guan-Jhong, Huang, Hui-Chi, Chen, Yu-Chang, Chang, Chi-I, Wang, Sheng-Yang, Chen, Ih-Sheng, Tseng, Yen-Hsueh, Chien, Shih-Chang, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268235/
https://www.ncbi.nlm.nih.gov/pubmed/22728355
http://dx.doi.org/10.3390/molecules17066585
Descripción
Sumario:A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC(50) values of 1.4–179.9 μM.

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