A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity

A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), w...

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Autores principales: Yang, Chung-Ping, Huang, Guan-Jhong, Huang, Hui-Chi, Chen, Yu-Chang, Chang, Chi-I, Wang, Sheng-Yang, Chen, Ih-Sheng, Tseng, Yen-Hsueh, Chien, Shih-Chang, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268235/
https://www.ncbi.nlm.nih.gov/pubmed/22728355
http://dx.doi.org/10.3390/molecules17066585
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author Yang, Chung-Ping
Huang, Guan-Jhong
Huang, Hui-Chi
Chen, Yu-Chang
Chang, Chi-I
Wang, Sheng-Yang
Chen, Ih-Sheng
Tseng, Yen-Hsueh
Chien, Shih-Chang
Kuo, Yueh-Hsiung
author_facet Yang, Chung-Ping
Huang, Guan-Jhong
Huang, Hui-Chi
Chen, Yu-Chang
Chang, Chi-I
Wang, Sheng-Yang
Chen, Ih-Sheng
Tseng, Yen-Hsueh
Chien, Shih-Chang
Kuo, Yueh-Hsiung
author_sort Yang, Chung-Ping
collection PubMed
description A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC(50) values of 1.4–179.9 μM.
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spelling pubmed-62682352018-12-12 A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity Yang, Chung-Ping Huang, Guan-Jhong Huang, Hui-Chi Chen, Yu-Chang Chang, Chi-I Wang, Sheng-Yang Chen, Ih-Sheng Tseng, Yen-Hsueh Chien, Shih-Chang Kuo, Yueh-Hsiung Molecules Article A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC(50) values of 1.4–179.9 μM. MDPI 2012-05-31 /pmc/articles/PMC6268235/ /pubmed/22728355 http://dx.doi.org/10.3390/molecules17066585 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Chung-Ping
Huang, Guan-Jhong
Huang, Hui-Chi
Chen, Yu-Chang
Chang, Chi-I
Wang, Sheng-Yang
Chen, Ih-Sheng
Tseng, Yen-Hsueh
Chien, Shih-Chang
Kuo, Yueh-Hsiung
A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title_full A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title_fullStr A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title_full_unstemmed A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title_short A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
title_sort new butanolide compound from the aerial part of lindera akoensis with anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268235/
https://www.ncbi.nlm.nih.gov/pubmed/22728355
http://dx.doi.org/10.3390/molecules17066585
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