Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)

A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3)...

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Autores principales: Mukhtar, Mat Ropi, Osman, Norfaizah, Awang, Khalijah, Hazni, Hazrina, Qureshi, Ahmad Kaleem, Hadi, A. Hamid A., Zaima, Kazuma, Morita, Hiroshi, Litaudon, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268236/
https://www.ncbi.nlm.nih.gov/pubmed/22205092
http://dx.doi.org/10.3390/molecules17010267
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author Mukhtar, Mat Ropi
Osman, Norfaizah
Awang, Khalijah
Hazni, Hazrina
Qureshi, Ahmad Kaleem
Hadi, A. Hamid A.
Zaima, Kazuma
Morita, Hiroshi
Litaudon, Marc
author_facet Mukhtar, Mat Ropi
Osman, Norfaizah
Awang, Khalijah
Hazni, Hazrina
Qureshi, Ahmad Kaleem
Hadi, A. Hamid A.
Zaima, Kazuma
Morita, Hiroshi
Litaudon, Marc
author_sort Mukhtar, Mat Ropi
collection PubMed
description A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1–3 after injection of each sample at 1 × 10(−5) M.
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spelling pubmed-62682362018-12-11 Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae) Mukhtar, Mat Ropi Osman, Norfaizah Awang, Khalijah Hazni, Hazrina Qureshi, Ahmad Kaleem Hadi, A. Hamid A. Zaima, Kazuma Morita, Hiroshi Litaudon, Marc Molecules Article A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1–3 after injection of each sample at 1 × 10(−5) M. MDPI 2011-12-28 /pmc/articles/PMC6268236/ /pubmed/22205092 http://dx.doi.org/10.3390/molecules17010267 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mukhtar, Mat Ropi
Osman, Norfaizah
Awang, Khalijah
Hazni, Hazrina
Qureshi, Ahmad Kaleem
Hadi, A. Hamid A.
Zaima, Kazuma
Morita, Hiroshi
Litaudon, Marc
Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title_full Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title_fullStr Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title_full_unstemmed Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title_short Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd.(Rubiaceae)
title_sort neonaucline, a new indole alkaloid from the leaves of ochreinauclea maingayii (hook. f.) ridsd.(rubiaceae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268236/
https://www.ncbi.nlm.nih.gov/pubmed/22205092
http://dx.doi.org/10.3390/molecules17010267
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