Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A

In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The resu...

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Autores principales: Wang, Wen-Long, Chen, Hai-Jun, Ma, Wei-Ping, Gu, Min, Fan, Min-Zhi, Li, Jing-Ya, Feng, Bainian, Nan, Fa-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268252/
https://www.ncbi.nlm.nih.gov/pubmed/23222900
http://dx.doi.org/10.3390/molecules171214522
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author Wang, Wen-Long
Chen, Hai-Jun
Ma, Wei-Ping
Gu, Min
Fan, Min-Zhi
Li, Jing-Ya
Feng, Bainian
Nan, Fa-Jun
author_facet Wang, Wen-Long
Chen, Hai-Jun
Ma, Wei-Ping
Gu, Min
Fan, Min-Zhi
Li, Jing-Ya
Feng, Bainian
Nan, Fa-Jun
author_sort Wang, Wen-Long
collection PubMed
description In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A.
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spelling pubmed-62682522018-12-14 Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A Wang, Wen-Long Chen, Hai-Jun Ma, Wei-Ping Gu, Min Fan, Min-Zhi Li, Jing-Ya Feng, Bainian Nan, Fa-Jun Molecules Article In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A. MDPI 2012-12-07 /pmc/articles/PMC6268252/ /pubmed/23222900 http://dx.doi.org/10.3390/molecules171214522 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Wen-Long
Chen, Hai-Jun
Ma, Wei-Ping
Gu, Min
Fan, Min-Zhi
Li, Jing-Ya
Feng, Bainian
Nan, Fa-Jun
Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title_full Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title_fullStr Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title_full_unstemmed Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title_short Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
title_sort synthesis and antiviral activity of conformational analogues of leucamide a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268252/
https://www.ncbi.nlm.nih.gov/pubmed/23222900
http://dx.doi.org/10.3390/molecules171214522
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