Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates

The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent therm...

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Autores principales: Zaky, Omniya Sayed, Moustafa, Moustafa Sherief, Selim, Maghraby Ali, El-Maghraby, Awatef Mohamed, Elnagdi, Mohamed Hilmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268266/
https://www.ncbi.nlm.nih.gov/pubmed/22609783
http://dx.doi.org/10.3390/molecules17055924
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author Zaky, Omniya Sayed
Moustafa, Moustafa Sherief
Selim, Maghraby Ali
El-Maghraby, Awatef Mohamed
Elnagdi, Mohamed Hilmy
author_facet Zaky, Omniya Sayed
Moustafa, Moustafa Sherief
Selim, Maghraby Ali
El-Maghraby, Awatef Mohamed
Elnagdi, Mohamed Hilmy
author_sort Zaky, Omniya Sayed
collection PubMed
description The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives.
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spelling pubmed-62682662018-12-20 Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates Zaky, Omniya Sayed Moustafa, Moustafa Sherief Selim, Maghraby Ali El-Maghraby, Awatef Mohamed Elnagdi, Mohamed Hilmy Molecules Article The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives. MDPI 2012-05-18 /pmc/articles/PMC6268266/ /pubmed/22609783 http://dx.doi.org/10.3390/molecules17055924 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zaky, Omniya Sayed
Moustafa, Moustafa Sherief
Selim, Maghraby Ali
El-Maghraby, Awatef Mohamed
Elnagdi, Mohamed Hilmy
Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title_full Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title_fullStr Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title_full_unstemmed Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title_short Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
title_sort scope and limitations of a novel synthesis of 3-arylazonicotinates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268266/
https://www.ncbi.nlm.nih.gov/pubmed/22609783
http://dx.doi.org/10.3390/molecules17055924
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