Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)

A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2...

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Autores principales: Liew, Sook Yee, Mukhtar, Mat Ropi, Hadi, A. Hamid A., Awang, Khalijah, Mustafa, Mohd Rais, Zaima, Kazumasa, Morita, Hiroshi, Litaudon, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268295/
https://www.ncbi.nlm.nih.gov/pubmed/22469596
http://dx.doi.org/10.3390/molecules17044028
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author Liew, Sook Yee
Mukhtar, Mat Ropi
Hadi, A. Hamid A.
Awang, Khalijah
Mustafa, Mohd Rais
Zaima, Kazumasa
Morita, Hiroshi
Litaudon, Marc
author_facet Liew, Sook Yee
Mukhtar, Mat Ropi
Hadi, A. Hamid A.
Awang, Khalijah
Mustafa, Mohd Rais
Zaima, Kazumasa
Morita, Hiroshi
Litaudon, Marc
author_sort Liew, Sook Yee
collection PubMed
description A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete (13)C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10(−5) M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10(−5) M) on an isolated rat aorta.
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spelling pubmed-62682952018-12-11 Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†) Liew, Sook Yee Mukhtar, Mat Ropi Hadi, A. Hamid A. Awang, Khalijah Mustafa, Mohd Rais Zaima, Kazumasa Morita, Hiroshi Litaudon, Marc Molecules Article A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete (13)C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10(−5) M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10(−5) M) on an isolated rat aorta. MDPI 2012-04-02 /pmc/articles/PMC6268295/ /pubmed/22469596 http://dx.doi.org/10.3390/molecules17044028 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liew, Sook Yee
Mukhtar, Mat Ropi
Hadi, A. Hamid A.
Awang, Khalijah
Mustafa, Mohd Rais
Zaima, Kazumasa
Morita, Hiroshi
Litaudon, Marc
Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title_full Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title_fullStr Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title_full_unstemmed Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title_short Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis (†)
title_sort naucline, a new indole alkaloid from the bark of nauclea officinalis (†)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268295/
https://www.ncbi.nlm.nih.gov/pubmed/22469596
http://dx.doi.org/10.3390/molecules17044028
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