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Aqueous Synthesis of 1-H-2-Substituted Benzimidazoles via Transition-Metal-Free Intramolecular Amination of Aryl Iodides

A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K(2)CO(3) in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole...

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Detalles Bibliográficos
Autores principales: Chen, Chunxia, Chen, Chen, Li, Bin, Tao, Jingwei, Peng, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268300/
https://www.ncbi.nlm.nih.gov/pubmed/23095894
http://dx.doi.org/10.3390/molecules171112506

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