Cargando…

Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes

Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP-glucuronosyltransferase 2B7 (UGT2B7) and in vivo CY...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Hye Young, Lee, Hyeri, Lim, Sae Rom, Kim, Jeong Han, Lee, Hye Suk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268312/ https://www.ncbi.nlm.nih.gov/pubmed/22252501 http://dx.doi.org/10.3390/molecules17010851

Ejemplares similares

Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Ji, Hye Young, et al.
Publicado: (2011)

Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes
por: Park, Ria, et al.
Publicado: (2021)

Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Jeong, Hyeon-Uk, et al.
Publicado: (2013)

Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes
por: Kutsuno, Yuki, et al.
Publicado: (2013)

In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes
por: Hong, Xiaodan, et al.
Publicado: (2017)

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
por: Shrestha, Riya, et al.
Publicado: (2018)

Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes
por: Li, Jia, et al.
Publicado: (2016)

In Vitro Inhibitory Effects of Synthetic Cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Kong, Tae Yeon, et al.
Publicado: (2018)

Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Ji, Hye Young, et al.
Publicado: (2012)

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
por: Illingworth, NA, et al.
Publicado: (2011)

Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term
por: Reimers, Arne, et al.
Publicado: (2010)

Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
por: Fretzayas, Andrew, et al.
Publicado: (2011)

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1
por: Cheng, Xuewei, et al.
Publicado: (2017)

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
por: Cho, Sung-joon, et al.
Publicado: (2016)

Developmental increases in rat hepatic microsomal UDP-glucuronosyltransferase activities toward xenoestrogens and decreases during pregnancy.
por: Matsumoto, Junya, et al.
Publicado: (2002)

Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia
por: Aoshima, Naoya, et al.
Publicado: (2014)

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD
por: Xie, Ying, et al.
Publicado: (2017)

Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5′-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Kwon, Soon-Sang, et al.
Publicado: (2016)

Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia
por: Shibuya, Ayako, et al.
Publicado: (2013)

Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes
por: Hwang, Deok-Kyu, et al.
Publicado: (2019)

Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity
por: Yuan, Ling-Min, et al.
Publicado: (2016)

The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis
por: Duthaler, Urs, et al.
Publicado: (2023)

Upregulation of UDP-Glucuronosyltransferases 1a1 and 1a7 Are Involved in Altered Puerarin Pharmacokinetics in Type II Diabetic Rats
por: Dong, Songtao, et al.
Publicado: (2018)

Demethylzeylasteral Exhibits Strong Inhibition towards UDP-Glucuronosyltransferase (UGT) 1A6 and 2B7
por: Zhao, Jin-Wen, et al.
Publicado: (2012)

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems
por: Wheeler, Abigail M., et al.
Publicado: (2023)

In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters
por: Kim, Sunjoo, et al.
Publicado: (2020)

Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study
por: Ma, Xuefeng, et al.
Publicado: (2022)

Genetic Polymorphisms of the UDP‐Glucuronosyltransferase 1A7 Gene and Irinotecan Toxicity in Japanese Cancer Patients
por: Ando, Maki, et al.
Publicado: (2002)

AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Traditional Herbal Formulas to as Treatments for Musculoskeletal Disorders: Their Inhibitory Effects on the Activities of Human Microsomal Cytochrome P450s and UDP-glucuronosyltransferases
por: Jin, Seong Eun, et al.
Publicado: (2016)

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1
por: Zhang, Beibei, et al.
Publicado: (2019)

Gossypol Exhibits a Strong Influence Towards UDP-Glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-Mediated Metabolism of Xenobiotics and Endogenous Substances
por: Zhang, Yong-Sheng, et al.
Publicado: (2012)

Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes
por: Choi, Won-Gu, et al.
Publicado: (2020)

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters
por: Kim, Sunjoo, et al.
Publicado: (2019)

Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen
por: Mehboob, Huma, et al.
Publicado: (2017)

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1
por: Pang, Hui-Lin, et al.
Publicado: (2022)

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs
por: Runge-Morris, Melissa, et al.
Publicado: (2009)

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases
por: Fujiwara, Ryoichi, et al.
Publicado: (2016)

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
por: Grant, Delores J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_p1vsji7h2p975t6iq8u5uduinq