Diterpenoids from the Buds of Pinus banksiana Lamb

Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were...

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Autores principales: Georges, Patricia, Legault, Jean, Lavoie, Serge, Grenon, Carole, Pichette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268314/
https://www.ncbi.nlm.nih.gov/pubmed/22890174
http://dx.doi.org/10.3390/molecules17089716
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author Georges, Patricia
Legault, Jean
Lavoie, Serge
Grenon, Carole
Pichette, André
author_facet Georges, Patricia
Legault, Jean
Lavoie, Serge
Grenon, Carole
Pichette, André
author_sort Georges, Patricia
collection PubMed
description Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line.
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spelling pubmed-62683142018-12-12 Diterpenoids from the Buds of Pinus banksiana Lamb Georges, Patricia Legault, Jean Lavoie, Serge Grenon, Carole Pichette, André Molecules Communication Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line. MDPI 2012-08-13 /pmc/articles/PMC6268314/ /pubmed/22890174 http://dx.doi.org/10.3390/molecules17089716 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Georges, Patricia
Legault, Jean
Lavoie, Serge
Grenon, Carole
Pichette, André
Diterpenoids from the Buds of Pinus banksiana Lamb
title Diterpenoids from the Buds of Pinus banksiana Lamb
title_full Diterpenoids from the Buds of Pinus banksiana Lamb
title_fullStr Diterpenoids from the Buds of Pinus banksiana Lamb
title_full_unstemmed Diterpenoids from the Buds of Pinus banksiana Lamb
title_short Diterpenoids from the Buds of Pinus banksiana Lamb
title_sort diterpenoids from the buds of pinus banksiana lamb
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268314/
https://www.ncbi.nlm.nih.gov/pubmed/22890174
http://dx.doi.org/10.3390/molecules17089716
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