Uses of Cyanoacetylhydrazine in Heterocyclic Synthesis: Novel Synthesis of Pyrazole Derivatives with Anti-tumor Activities

The reaction of cyanoacetylhydrazine with chloroacetyl chloride gave N'-(2-chloroacetyl)-2-cyanoacetohydrazide. The latter underwent cyclization to afford 1-(5 amino-3-hydroxy-1H-pyrazol-1-yl)-2-chloroethanone, which underwent nucleophilic substitution to give 3-(5-amino-3-hydroxy-1H-pyrazol-1-...

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Detalles Bibliográficos
Autores principales: Mohareb, Rafat M., El-Sayed, Nahed N. E., Abdelaziz, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268329/
https://www.ncbi.nlm.nih.gov/pubmed/22790561
http://dx.doi.org/10.3390/molecules17078449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268329/
https://www.ncbi.nlm.nih.gov/pubmed/22790561
http://dx.doi.org/10.3390/molecules17078449

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