Cargando…

Synthesis and Biological Evaluation of Thiophene Derivatives as Acetylcholinesterase Inhibitors

A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman’s method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Metho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ismail, Mohamed M., Kamel, Mona M., Mohamed, Lamia W., Faggal, Samar I., Galal, Mai A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268334/ https://www.ncbi.nlm.nih.gov/pubmed/22692245 http://dx.doi.org/10.3390/molecules17067217

Ejemplares similares

Synthesis of New Indole Derivatives Structurally Related to Donepezil and Their Biological Evaluation as Acetylcholinesterase Inhibitors
por: Ismail, Mohamed M., et al.
Publicado: (2012)

Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors
por: Hemaida, Aya Y., et al.
Publicado: (2021)

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors
por: Barakat, Assem, et al.
Publicado: (2020)

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase
por: Wang, Yue-Hu, et al.
Publicado: (2012)

Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
por: Gulçin, İlhami, et al.
Publicado: (2017)

Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors
por: Sukumaran, Sri Devi, et al.
Publicado: (2016)

Virtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors
por: Varadaraju, Kavitha Raj, et al.
Publicado: (2013)

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors
por: Mahgoub, Mohamed Y., et al.
Publicado: (2019)

Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves
por: Hassan, Heba Ali, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK
por: Vinh, Natalie B, et al.
Publicado: (2015)

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Synthesis and biological evaluation of benzothiazin-4-ones: a possible new class of acetylcholinesterase inhibitors
por: Berwaldt, Gabriele A., et al.
Publicado: (2018)

Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold
por: Suwanhom, Paptawan, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase
por: Wang, Dong-mei, et al.
Publicado: (2017)

Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer’s: Design, Synthesis, and Biological Evaluation
por: Gupta, Shraddha Manish, et al.
Publicado: (2022)

Synthesis, DFT investigations, antioxidant, antibacterial activity and SAR-study of novel thiophene-2-carboxamide derivatives
por: Metwally, Heba M., et al.
Publicado: (2023)

Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase
por: Khan, Shoaib, et al.
Publicado: (2022)

Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[b]thiophene Derivatives and Their Nanoparticles Targeting Colorectal Cancer
por: Kamal, Shimaa, et al.
Publicado: (2021)

Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors
por: Reshetnikov, Danila V., et al.
Publicado: (2022)

Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors
por: de Lima, Bruna R., et al.
Publicado: (2019)

New Acetylcholinesterase Inhibitors for Alzheimer's Disease
por: Mehta, Mona, et al.
Publicado: (2012)

Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase
por: Hassanzadeh, Motahareh, et al.
Publicado: (2021)

Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells
por: Taheri, Maryam, et al.
Publicado: (2022)

Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer’s disease
por: Pourtaher, Hormoz, et al.
Publicado: (2022)

Natural products as sources of acetylcholinesterase inhibitors: Synthesis, biological activities, and molecular docking studies of osthole-based ester derivatives
por: Yu, Xiang, et al.
Publicado: (2022)

Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity
por: Tran, Thai-Son, et al.
Publicado: (2020)

Photophysical properties and fluorosolvatochromism of D–π–A thiophene based derivatives
por: Sabek, Hussain A. Z., et al.
Publicado: (2020)

Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate
por: Guo, Tao, et al.
Publicado: (2019)

Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies
por: Bhat, Mashooq Ahmad, et al.
Publicado: (2018)

Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
por: Soyer, Zeynep, et al.
Publicado: (2016)

Design, Synthesis and Bioactivity Evaluation of Coumarin–BMT Hybrids as New Acetylcholinesterase Inhibitors
por: Zeng, Fanxin, et al.
Publicado: (2022)

Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015–Present: Synthesis and Biological Activity
por: Eckroat, Todd J., et al.
Publicado: (2020)

Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin
por: Tran, The-Huan, et al.
Publicado: (2021)

Xanthenedione Derivatives, New Promising Antioxidant and Acetylcholinesterase Inhibitor Agents
por: Seca, Ana M. L., et al.
Publicado: (2014)

Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster
por: Hai, Abdul, et al.
Publicado: (2013)

Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor
por: Sun, Shouyuan, et al.
Publicado: (2022)

Three (―)-cytisine derivatives and 1-hydroxyquinopimaric acid as acetylcholinesterase inhibitors
por: García-García, J. Daniel, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging
por: Haider, Ahmed, et al.
Publicado: (2016)

Recent Advances in the Synthesis of Thiophene Derivatives by Cyclization of Functionalized Alkynes
por: Mancuso, Raffaella, et al.
Publicado: (2014)

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases
por: Guo, Yan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2si4q86hh9ukt6n8f535k4eg1k