Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones

A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthes...

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Detalles Bibliográficos
Autores principales: Farghaly, Thoraya Abdel Reheem, Edrees, Mastoura Mohamed, Mosselhi, Mosselhi Abdelnabi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268342/
https://www.ncbi.nlm.nih.gov/pubmed/22797779
http://dx.doi.org/10.3390/molecules17078483
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author Farghaly, Thoraya Abdel Reheem
Edrees, Mastoura Mohamed
Mosselhi, Mosselhi Abdelnabi
author_facet Farghaly, Thoraya Abdel Reheem
Edrees, Mastoura Mohamed
Mosselhi, Mosselhi Abdelnabi
author_sort Farghaly, Thoraya Abdel Reheem
collection PubMed
description A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
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spelling pubmed-62683422018-12-12 Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones Farghaly, Thoraya Abdel Reheem Edrees, Mastoura Mohamed Mosselhi, Mosselhi Abdelnabi Molecules Article A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria. MDPI 2012-07-13 /pmc/articles/PMC6268342/ /pubmed/22797779 http://dx.doi.org/10.3390/molecules17078483 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Farghaly, Thoraya Abdel Reheem
Edrees, Mastoura Mohamed
Mosselhi, Mosselhi Abdelnabi
Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title_full Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title_fullStr Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title_full_unstemmed Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title_short Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
title_sort synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1h)-diones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268342/
https://www.ncbi.nlm.nih.gov/pubmed/22797779
http://dx.doi.org/10.3390/molecules17078483
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AT mosselhimosselhiabdelnabi synthesistautomericstructureandantimicrobialactivityof3arylhydrazono4phenyl124triazepino23aquinazoline271hdiones

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