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trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness

Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with stan...

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Autores principales: Rossi, Damiano, Guerrini, Alessandra, Bruni, Renato, Brognara, Eleonora, Borgatti, Monica, Gambari, Roberto, Maietti, Silvia, Sacchetti, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268383/
https://www.ncbi.nlm.nih.gov/pubmed/23090020
http://dx.doi.org/10.3390/molecules171012393
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author Rossi, Damiano
Guerrini, Alessandra
Bruni, Renato
Brognara, Eleonora
Borgatti, Monica
Gambari, Roberto
Maietti, Silvia
Sacchetti, Gianni
author_facet Rossi, Damiano
Guerrini, Alessandra
Bruni, Renato
Brognara, Eleonora
Borgatti, Monica
Gambari, Roberto
Maietti, Silvia
Sacchetti, Gianni
author_sort Rossi, Damiano
collection PubMed
description Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits.
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spelling pubmed-62683832018-12-12 trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness Rossi, Damiano Guerrini, Alessandra Bruni, Renato Brognara, Eleonora Borgatti, Monica Gambari, Roberto Maietti, Silvia Sacchetti, Gianni Molecules Article Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits. MDPI 2012-10-22 /pmc/articles/PMC6268383/ /pubmed/23090020 http://dx.doi.org/10.3390/molecules171012393 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rossi, Damiano
Guerrini, Alessandra
Bruni, Renato
Brognara, Eleonora
Borgatti, Monica
Gambari, Roberto
Maietti, Silvia
Sacchetti, Gianni
trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title_full trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title_fullStr trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title_full_unstemmed trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title_short trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
title_sort trans-resveratrol in nutraceuticals: issues in retail quality and effectiveness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268383/
https://www.ncbi.nlm.nih.gov/pubmed/23090020
http://dx.doi.org/10.3390/molecules171012393
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