A General Synthesis of Bis-indolylpiperazine-2,5-diones

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimet...

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Detalles Bibliográficos
Autores principales: Crooke, Stephen, Whitlock, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268405/
https://www.ncbi.nlm.nih.gov/pubmed/23519256
http://dx.doi.org/10.3390/molecules171214841
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author Crooke, Stephen
Whitlock, Christine
author_facet Crooke, Stephen
Whitlock, Christine
author_sort Crooke, Stephen
collection PubMed
description The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by (1)H-NMR.
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spelling pubmed-62684052018-12-14 A General Synthesis of Bis-indolylpiperazine-2,5-diones Crooke, Stephen Whitlock, Christine Molecules Article The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by (1)H-NMR. MDPI 2012-12-13 /pmc/articles/PMC6268405/ /pubmed/23519256 http://dx.doi.org/10.3390/molecules171214841 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Crooke, Stephen
Whitlock, Christine
A General Synthesis of Bis-indolylpiperazine-2,5-diones
title A General Synthesis of Bis-indolylpiperazine-2,5-diones
title_full A General Synthesis of Bis-indolylpiperazine-2,5-diones
title_fullStr A General Synthesis of Bis-indolylpiperazine-2,5-diones
title_full_unstemmed A General Synthesis of Bis-indolylpiperazine-2,5-diones
title_short A General Synthesis of Bis-indolylpiperazine-2,5-diones
title_sort general synthesis of bis-indolylpiperazine-2,5-diones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268405/
https://www.ncbi.nlm.nih.gov/pubmed/23519256
http://dx.doi.org/10.3390/molecules171214841
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