The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields....

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Detalles Bibliográficos
Autores principales: Migliorini, Antonella, Oliviero, Chiara, Gasperi, Tecla, Loreto, Maria Antonietta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268423/
https://www.ncbi.nlm.nih.gov/pubmed/22508331
http://dx.doi.org/10.3390/molecules17044508
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author Migliorini, Antonella
Oliviero, Chiara
Gasperi, Tecla
Loreto, Maria Antonietta
author_facet Migliorini, Antonella
Oliviero, Chiara
Gasperi, Tecla
Loreto, Maria Antonietta
author_sort Migliorini, Antonella
collection PubMed
description The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
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spelling pubmed-62684232018-12-11 The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles Migliorini, Antonella Oliviero, Chiara Gasperi, Tecla Loreto, Maria Antonietta Molecules Article The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules. MDPI 2012-04-16 /pmc/articles/PMC6268423/ /pubmed/22508331 http://dx.doi.org/10.3390/molecules17044508 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Migliorini, Antonella
Oliviero, Chiara
Gasperi, Tecla
Loreto, Maria Antonietta
The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title_full The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title_fullStr The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title_full_unstemmed The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title_short The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles
title_sort suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268423/
https://www.ncbi.nlm.nih.gov/pubmed/22508331
http://dx.doi.org/10.3390/molecules17044508
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