Cargando…

New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a–e which differ from sorafenib in their amide part. A 4-step synthetic pathway includes preparation of 4-chloropyri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Babić, Željka, Crkvenčić, Maja, Rajić, Zrinka, Mikecin, Ana-Matea, Kralj, Marijeta, Balzarini, Jan, Petrova, Mariya, Vanderleyden, Jos, Zorc, Branka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268433/ https://www.ncbi.nlm.nih.gov/pubmed/22269830 http://dx.doi.org/10.3390/molecules17011124

Ejemplares similares

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents
por: Beus, Maja, et al.
Publicado: (2019)

The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity
por: Rajić, Zrinka, et al.
Publicado: (2010)

Synthesis and Biological Evaluation of Harmirins, Novel Harmine–Coumarin Hybrids as Potential Anticancer Agents
por: Pavić, Kristina, et al.
Publicado: (2021)

Primaquine derivatives: Modifications of the terminal amino group
por: Zorc, Branka, et al.
Publicado: (2019)

Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract
por: Otto, Christoph, et al.
Publicado: (2016)

A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors
por: Orienti, Isabella, et al.
Publicado: (2019)

Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule
por: Zhang, Issan, et al.
Publicado: (2018)

Potential roles of Garcinia family as antimetabolic syndrome
por: Kuswandi, Asep, et al.
Publicado: (2022)

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors
por: Rajić, Zrinka, et al.
Publicado: (2018)

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents
por: Beus, Maja, et al.
Publicado: (2018)

Harmicens, Novel Harmine and Ferrocene Hybrids: Design, Synthesis and Biological Activity
por: Poje, Goran, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type
por: Pavić, Kristina, et al.
Publicado: (2016)

Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells
por: Püschel, Franziska, et al.
Publicado: (2020)

Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism
por: Keating, Elisa, et al.
Publicado: (2018)

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity
por: Cindrić, Maja, et al.
Publicado: (2019)

Novel Harmicines with Improved Potency against Plasmodium
por: Marinović, Marina, et al.
Publicado: (2020)

Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents
por: Hernández-Reséndiz, Ileana, et al.
Publicado: (2020)

Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation
por: Petrova, Mariya I., et al.
Publicado: (2016)

NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ
por: Chen, Yu, et al.
Publicado: (2018)

Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome
por: Palachai, Nut, et al.
Publicado: (2019)

Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells
por: Trinh, Anne, et al.
Publicado: (2021)

Advances in oligosaccharides production from brown seaweeds: extraction, characterization, antimetabolic syndrome, and other potential applications
por: Krishna Perumal, Pitchurajan, et al.
Publicado: (2023)

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications
por: Férir, Geoffrey, et al.
Publicado: (2013)

Photochemical Reactivity of Naphthol-Naphthalimide Conjugates and Their Biological Activity
por: Sambol, Matija, et al.
Publicado: (2021)

A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel
por: Čačić, Ana, et al.
Publicado: (2023)

Expression of fluorescent proteins in Lactobacillus rhamnosus to study host–microbe and microbe–microbe interactions
por: Spacova, Irina, et al.
Publicado: (2017)

Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives
por: El-Sayed, Nahed N. E., et al.
Publicado: (2019)

Probing the applicability of autotransporter based surface display with the EstA autotransporter of Pseudomonas stutzeri A15
por: Nicolay, Toon, et al.
Publicado: (2012)

Synthesis, characterization, and antiproliferative evaluation of novel sorafenib analogs for the treatment of hepatocellular carcinoma
por: Jihad, Marwan Imad, et al.
Publicado: (2023)

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300
por: Malik, Shweta, et al.
Publicado: (2016)

4. Global Approach to Biomedicine: Functional Genomics and Proteomics
por: Pavelić, Krešimir, et al.
Publicado: (2008)

Global Approach to Biomedicine: Functional Genomics and Proteomics
por: Pavelic, Kresimir, et al.
Publicado: (2005)

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
por: Perković, I., et al.
Publicado: (2012)

Itaconic acid hybrids as potential anticancer agents
por: Perković, Ivana, et al.
Publicado: (2020)

Comparative Genomic and Phenotypic Analysis of the Vaginal Probiotic Lactobacillus rhamnosus GR-1
por: Petrova, Mariya I., et al.
Publicado: (2018)

Antiproliferative effects of somatostatin analogs in endocrine tumours
por: Zatelli, Maria Chiara
Publicado: (2009)

Inflammatory Biomarkers Affecting Survival Prognosis in Patients Receiving Veno-Venous ECMO for Severe COVID-19 Pneumonia
por: Drmić, Željka, et al.
Publicado: (2023)

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones
por: Onnis, Valentina, et al.
Publicado: (2016)

The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens
por: Petrova, Mariya I., et al.
Publicado: (2016)

Antiproliferative effects of sorafenib and pegylated IFN-α2b on human liver cancer cells in vitro and in vivo
por: KUSANO, HIRONORI, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_maf7ufcsnfrku0nk0jrr6ud79g