Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives

A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data ((1)H-NMR, (13)C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopath...

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Autores principales: Wu, Zhibing, Hu, Deyu, Kuang, Jiqing, Cai, Hua, Wu, Shixi, Xue, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268469/
https://www.ncbi.nlm.nih.gov/pubmed/23201640
http://dx.doi.org/10.3390/molecules171214205
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author Wu, Zhibing
Hu, Deyu
Kuang, Jiqing
Cai, Hua
Wu, Shixi
Xue, Wei
author_facet Wu, Zhibing
Hu, Deyu
Kuang, Jiqing
Cai, Hua
Wu, Shixi
Xue, Wei
author_sort Wu, Zhibing
collection PubMed
description A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data ((1)H-NMR, (13)C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and 6c displayed more than 50% inhibition activities against G. zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid.
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spelling pubmed-62684692018-12-14 Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives Wu, Zhibing Hu, Deyu Kuang, Jiqing Cai, Hua Wu, Shixi Xue, Wei Molecules Article A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data ((1)H-NMR, (13)C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and 6c displayed more than 50% inhibition activities against G. zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid. MDPI 2012-11-30 /pmc/articles/PMC6268469/ /pubmed/23201640 http://dx.doi.org/10.3390/molecules171214205 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Zhibing
Hu, Deyu
Kuang, Jiqing
Cai, Hua
Wu, Shixi
Xue, Wei
Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title_full Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title_fullStr Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title_full_unstemmed Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title_short Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
title_sort synthesis and antifungal activity of n-(substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxamide derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268469/
https://www.ncbi.nlm.nih.gov/pubmed/23201640
http://dx.doi.org/10.3390/molecules171214205
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