Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is re...

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Detalles Bibliográficos
Autores principales: Liu, Jian-Yu, Guan, Ying-Li, Zou, Li-Bo, Gong, Yi-Xia, Hua, Hui-Ming, Xu, Yong-Nan, Zhang, Hui, Yu, Zong-Gui, Fan, Wen-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268475/
https://www.ncbi.nlm.nih.gov/pubmed/22572934
http://dx.doi.org/10.3390/molecules17055520
Descripción
Sumario:Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid(25–35) (Aβ(25–35)) on human neuroblastoma SH-SY5Y cells.

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