Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is re...

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Autores principales: Liu, Jian-Yu, Guan, Ying-Li, Zou, Li-Bo, Gong, Yi-Xia, Hua, Hui-Ming, Xu, Yong-Nan, Zhang, Hui, Yu, Zong-Gui, Fan, Wen-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268475/
https://www.ncbi.nlm.nih.gov/pubmed/22572934
http://dx.doi.org/10.3390/molecules17055520
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author Liu, Jian-Yu
Guan, Ying-Li
Zou, Li-Bo
Gong, Yi-Xia
Hua, Hui-Ming
Xu, Yong-Nan
Zhang, Hui
Yu, Zong-Gui
Fan, Wen-Hao
author_facet Liu, Jian-Yu
Guan, Ying-Li
Zou, Li-Bo
Gong, Yi-Xia
Hua, Hui-Ming
Xu, Yong-Nan
Zhang, Hui
Yu, Zong-Gui
Fan, Wen-Hao
author_sort Liu, Jian-Yu
collection PubMed
description Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid(25–35) (Aβ(25–35)) on human neuroblastoma SH-SY5Y cells.
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spelling pubmed-62684752018-12-20 Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua Liu, Jian-Yu Guan, Ying-Li Zou, Li-Bo Gong, Yi-Xia Hua, Hui-Ming Xu, Yong-Nan Zhang, Hui Yu, Zong-Gui Fan, Wen-Hao Molecules Article Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid(25–35) (Aβ(25–35)) on human neuroblastoma SH-SY5Y cells. MDPI 2012-05-09 /pmc/articles/PMC6268475/ /pubmed/22572934 http://dx.doi.org/10.3390/molecules17055520 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Jian-Yu
Guan, Ying-Li
Zou, Li-Bo
Gong, Yi-Xia
Hua, Hui-Ming
Xu, Yong-Nan
Zhang, Hui
Yu, Zong-Gui
Fan, Wen-Hao
Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title_full Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title_fullStr Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title_full_unstemmed Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title_short Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua
title_sort saponins with neuroprotective effects from the roots of pulsatilla cernua
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268475/
https://www.ncbi.nlm.nih.gov/pubmed/22572934
http://dx.doi.org/10.3390/molecules17055520
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