Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 1–3), were isolated along with ten known compounds 4–13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 1–3 were elucidated on the basis of their spectro...

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Autores principales: Wang, Qiuhong, Wang, Changfu, Zuo, Yueming, Wang, Zhibin, Yang, Bingyou, Kuang, Haixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268518/
https://www.ncbi.nlm.nih.gov/pubmed/23250029
http://dx.doi.org/10.3390/molecules171215013
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author Wang, Qiuhong
Wang, Changfu
Zuo, Yueming
Wang, Zhibin
Yang, Bingyou
Kuang, Haixue
author_facet Wang, Qiuhong
Wang, Changfu
Zuo, Yueming
Wang, Zhibin
Yang, Bingyou
Kuang, Haixue
author_sort Wang, Qiuhong
collection PubMed
description Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 1–3), were isolated along with ten known compounds 4–13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 1–3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1–13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25–25)), respectively. As a result, germacrane-type sesquiterpenoids 1–4 and lignans 5–7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
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spelling pubmed-62685182018-12-14 Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells Wang, Qiuhong Wang, Changfu Zuo, Yueming Wang, Zhibin Yang, Bingyou Kuang, Haixue Molecules Article Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 1–3), were isolated along with ten known compounds 4–13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 1–3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1–13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25–25)), respectively. As a result, germacrane-type sesquiterpenoids 1–4 and lignans 5–7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD. MDPI 2012-12-18 /pmc/articles/PMC6268518/ /pubmed/23250029 http://dx.doi.org/10.3390/molecules171215013 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Qiuhong
Wang, Changfu
Zuo, Yueming
Wang, Zhibin
Yang, Bingyou
Kuang, Haixue
Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title_full Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title_fullStr Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title_full_unstemmed Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title_short Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
title_sort compounds from the roots and rhizomes of valeriana amurensis protect against neurotoxicity in pc12 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268518/
https://www.ncbi.nlm.nih.gov/pubmed/23250029
http://dx.doi.org/10.3390/molecules171215013
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