Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates

23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumo...

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Detalles Bibliográficos
Autores principales: Bi, Yi, Xu, Jinyi, Sun, Fei, Wu, Xiaoming, Ye, Wencai, Sun, Yijun, Huang, Wenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268522/
https://www.ncbi.nlm.nih.gov/pubmed/22832884
http://dx.doi.org/10.3390/molecules17088832
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author Bi, Yi
Xu, Jinyi
Sun, Fei
Wu, Xiaoming
Ye, Wencai
Sun, Yijun
Huang, Wenwen
author_facet Bi, Yi
Xu, Jinyi
Sun, Fei
Wu, Xiaoming
Ye, Wencai
Sun, Yijun
Huang, Wenwen
author_sort Bi, Yi
collection PubMed
description 23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50) values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.
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spelling pubmed-62685222018-12-12 Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates Bi, Yi Xu, Jinyi Sun, Fei Wu, Xiaoming Ye, Wencai Sun, Yijun Huang, Wenwen Molecules Article 23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50) values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo. MDPI 2012-07-25 /pmc/articles/PMC6268522/ /pubmed/22832884 http://dx.doi.org/10.3390/molecules17088832 Text en © 2012 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bi, Yi
Xu, Jinyi
Sun, Fei
Wu, Xiaoming
Ye, Wencai
Sun, Yijun
Huang, Wenwen
Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title_full Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title_fullStr Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title_full_unstemmed Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title_short Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
title_sort synthesis and biological activity of 23-hydroxybetulinic acid c-28 ester derivatives as antitumor agent candidates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268522/
https://www.ncbi.nlm.nih.gov/pubmed/22832884
http://dx.doi.org/10.3390/molecules17088832
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