Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurati...

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Autores principales: Luo, Du Qiang, Zhang, Lei, Shi, Bao Zhong, Song, Xiao Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268523/
https://www.ncbi.nlm.nih.gov/pubmed/22805506
http://dx.doi.org/10.3390/molecules17078554
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author Luo, Du Qiang
Zhang, Lei
Shi, Bao Zhong
Song, Xiao Mei
author_facet Luo, Du Qiang
Zhang, Lei
Shi, Bao Zhong
Song, Xiao Mei
author_sort Luo, Du Qiang
collection PubMed
description Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC(50) values of 12.6, 31.7 and 5.4 µg/mL, respectively.
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spelling pubmed-62685232018-12-12 Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua Luo, Du Qiang Zhang, Lei Shi, Bao Zhong Song, Xiao Mei Molecules Article Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC(50) values of 12.6, 31.7 and 5.4 µg/mL, respectively. MDPI 2012-07-17 /pmc/articles/PMC6268523/ /pubmed/22805506 http://dx.doi.org/10.3390/molecules17078554 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Luo, Du Qiang
Zhang, Lei
Shi, Bao Zhong
Song, Xiao Mei
Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title_full Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title_fullStr Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title_full_unstemmed Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title_short Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua
title_sort two new oxysporone derivatives from the fermentation broth of the endophytic plant fungus pestalotiopsis karstenii isolated from stems of camellia sasanqua
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268523/
https://www.ncbi.nlm.nih.gov/pubmed/22805506
http://dx.doi.org/10.3390/molecules17078554
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