A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists

A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient pr...

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Detalles Bibliográficos
Autores principales: Bao, Xiaofeng, Liu, Duliang, Jin, Yanyan, Yang, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268526/
https://www.ncbi.nlm.nih.gov/pubmed/23208464
http://dx.doi.org/10.3390/molecules171214288
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author Bao, Xiaofeng
Liu, Duliang
Jin, Yanyan
Yang, Yao
author_facet Bao, Xiaofeng
Liu, Duliang
Jin, Yanyan
Yang, Yao
author_sort Bao, Xiaofeng
collection PubMed
description A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.
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spelling pubmed-62685262018-12-14 A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists Bao, Xiaofeng Liu, Duliang Jin, Yanyan Yang, Yao Molecules Article A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7. MDPI 2012-12-03 /pmc/articles/PMC6268526/ /pubmed/23208464 http://dx.doi.org/10.3390/molecules171214288 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bao, Xiaofeng
Liu, Duliang
Jin, Yanyan
Yang, Yao
A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title_full A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title_fullStr A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title_full_unstemmed A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title_short A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
title_sort facile synthesis for novel loperamide analogs as potential μ opioid receptor agonists
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268526/
https://www.ncbi.nlm.nih.gov/pubmed/23208464
http://dx.doi.org/10.3390/molecules171214288
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