Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp

A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cn...

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Autores principales: Cheng, Ching-Hsiao, Chung, Hsu-Ming, Hwang, Tsong-Long, Lu, Mei-Chin, Wen, Zhi-Hong, Kuo, Yueh-Hsiung, Wang, Wei-Hsien, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268545/
https://www.ncbi.nlm.nih.gov/pubmed/22871646
http://dx.doi.org/10.3390/molecules17089443
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author Cheng, Ching-Hsiao
Chung, Hsu-Ming
Hwang, Tsong-Long
Lu, Mei-Chin
Wen, Zhi-Hong
Kuo, Yueh-Hsiung
Wang, Wei-Hsien
Sung, Ping-Jyun
author_facet Cheng, Ching-Hsiao
Chung, Hsu-Ming
Hwang, Tsong-Long
Lu, Mei-Chin
Wen, Zhi-Hong
Kuo, Yueh-Hsiung
Wang, Wei-Hsien
Sung, Ping-Jyun
author_sort Cheng, Ching-Hsiao
collection PubMed
description A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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spelling pubmed-62685452018-12-12 Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp Cheng, Ching-Hsiao Chung, Hsu-Ming Hwang, Tsong-Long Lu, Mei-Chin Wen, Zhi-Hong Kuo, Yueh-Hsiung Wang, Wei-Hsien Sung, Ping-Jyun Molecules Article A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. MDPI 2012-08-07 /pmc/articles/PMC6268545/ /pubmed/22871646 http://dx.doi.org/10.3390/molecules17089443 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cheng, Ching-Hsiao
Chung, Hsu-Ming
Hwang, Tsong-Long
Lu, Mei-Chin
Wen, Zhi-Hong
Kuo, Yueh-Hsiung
Wang, Wei-Hsien
Sung, Ping-Jyun
Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title_full Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title_fullStr Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title_full_unstemmed Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title_short Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp
title_sort echinoclerodane a: a new bioactive clerodane-type diterpenoid from a gorgonian coral echinomuricea sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268545/
https://www.ncbi.nlm.nih.gov/pubmed/22871646
http://dx.doi.org/10.3390/molecules17089443
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