Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells

Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs...

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Autores principales: Kaushik, Nagendra Kumar, Attri, Pankaj, Kaushik, Neha, Choi, Eun Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268550/
https://www.ncbi.nlm.nih.gov/pubmed/23174892
http://dx.doi.org/10.3390/molecules171213727
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author Kaushik, Nagendra Kumar
Attri, Pankaj
Kaushik, Neha
Choi, Eun Ha
author_facet Kaushik, Nagendra Kumar
Attri, Pankaj
Kaushik, Neha
Choi, Eun Ha
author_sort Kaushik, Nagendra Kumar
collection PubMed
description Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs; IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.
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spelling pubmed-62685502018-12-14 Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells Kaushik, Nagendra Kumar Attri, Pankaj Kaushik, Neha Choi, Eun Ha Molecules Article Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs; IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations. MDPI 2012-11-22 /pmc/articles/PMC6268550/ /pubmed/23174892 http://dx.doi.org/10.3390/molecules171213727 Text en © 2012 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kaushik, Nagendra Kumar
Attri, Pankaj
Kaushik, Neha
Choi, Eun Ha
Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title_full Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title_fullStr Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title_full_unstemmed Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title_short Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells
title_sort synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against t98g brain cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268550/
https://www.ncbi.nlm.nih.gov/pubmed/23174892
http://dx.doi.org/10.3390/molecules171213727
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