Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity

A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4′-hydroxy-2′-methoxyphenyl)-2-(2′′,4′′-dihydroxyphenyl)-1,3-propanediol-4′-O-β-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal sapo...

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Detalles Bibliográficos
Autores principales: Zhou, Zhong-Liu, Feng, Zong-Cai, Fu, Chun-Yan, Zhang, Hua-Lin, Xia, Jing-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268628/
https://www.ncbi.nlm.nih.gov/pubmed/22945028
http://dx.doi.org/10.3390/molecules170910494
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author Zhou, Zhong-Liu
Feng, Zong-Cai
Fu, Chun-Yan
Zhang, Hua-Lin
Xia, Jing-Min
author_facet Zhou, Zhong-Liu
Feng, Zong-Cai
Fu, Chun-Yan
Zhang, Hua-Lin
Xia, Jing-Min
author_sort Zhou, Zhong-Liu
collection PubMed
description A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4′-hydroxy-2′-methoxyphenyl)-2-(2′′,4′′-dihydroxyphenyl)-1,3-propanediol-4′-O-β-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal saponins. Their chemical structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. In addition, the inhibitory activity of all the isolates on Na(+)/K(+) ATPase was evaluated.
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spelling pubmed-62686282018-12-12 Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity Zhou, Zhong-Liu Feng, Zong-Cai Fu, Chun-Yan Zhang, Hua-Lin Xia, Jing-Min Molecules Article A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4′-hydroxy-2′-methoxyphenyl)-2-(2′′,4′′-dihydroxyphenyl)-1,3-propanediol-4′-O-β-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal saponins. Their chemical structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. In addition, the inhibitory activity of all the isolates on Na(+)/K(+) ATPase was evaluated. MDPI 2012-09-03 /pmc/articles/PMC6268628/ /pubmed/22945028 http://dx.doi.org/10.3390/molecules170910494 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhou, Zhong-Liu
Feng, Zong-Cai
Fu, Chun-Yan
Zhang, Hua-Lin
Xia, Jing-Min
Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title_full Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title_fullStr Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title_full_unstemmed Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title_short Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na(+)/K(+) ATPase Inhibitory Activity
title_sort steroidal and phenolic glycosides from the bulbs of lilium pumilum dc and their potential na(+)/k(+) atpase inhibitory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268628/
https://www.ncbi.nlm.nih.gov/pubmed/22945028
http://dx.doi.org/10.3390/molecules170910494
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