Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives

A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Ma, Hongli, Fu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268680/
https://www.ncbi.nlm.nih.gov/pubmed/22343404
http://dx.doi.org/10.3390/molecules17021992
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author Liu, Lei
Ma, Hongli
Fu, Bin
author_facet Liu, Lei
Ma, Hongli
Fu, Bin
author_sort Liu, Lei
collection PubMed
description A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.
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spelling pubmed-62686802018-12-10 Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives Liu, Lei Ma, Hongli Fu, Bin Molecules Article A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values. MDPI 2012-02-17 /pmc/articles/PMC6268680/ /pubmed/22343404 http://dx.doi.org/10.3390/molecules17021992 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Lei
Ma, Hongli
Fu, Bin
Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title_full Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title_fullStr Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title_full_unstemmed Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title_short Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives
title_sort allylic alkylations catalyzed by palladium-bis(oxazoline) complexes derived from heteroarylidene malonate derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268680/
https://www.ncbi.nlm.nih.gov/pubmed/22343404
http://dx.doi.org/10.3390/molecules17021992
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AT mahongli allylicalkylationscatalyzedbypalladiumbisoxazolinecomplexesderivedfromheteroarylidenemalonatederivatives
AT fubin allylicalkylationscatalyzedbypalladiumbisoxazolinecomplexesderivedfromheteroarylidenemalonatederivatives

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