Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery

Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated f...

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Detalles Bibliográficos
Autores principales: Bai, Yuhua, Lu, Ping, Han, Chenghua, Yu, Chunyue, Chen, Minggang, He, Fa, Yi, Dan, Wu, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268686/
https://www.ncbi.nlm.nih.gov/pubmed/23519263
http://dx.doi.org/10.3390/molecules171214918
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author Bai, Yuhua
Lu, Ping
Han, Chenghua
Yu, Chunyue
Chen, Minggang
He, Fa
Yi, Dan
Wu, Lijun
author_facet Bai, Yuhua
Lu, Ping
Han, Chenghua
Yu, Chunyue
Chen, Minggang
He, Fa
Yi, Dan
Wu, Lijun
author_sort Bai, Yuhua
collection PubMed
description Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it’s vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).
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spelling pubmed-62686862018-12-14 Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery Bai, Yuhua Lu, Ping Han, Chenghua Yu, Chunyue Chen, Minggang He, Fa Yi, Dan Wu, Lijun Molecules Article Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it’s vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs). MDPI 2012-12-13 /pmc/articles/PMC6268686/ /pubmed/23519263 http://dx.doi.org/10.3390/molecules171214918 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bai, Yuhua
Lu, Ping
Han, Chenghua
Yu, Chunyue
Chen, Minggang
He, Fa
Yi, Dan
Wu, Lijun
Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title_full Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title_fullStr Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title_full_unstemmed Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title_short Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
title_sort hydroxysafflor yellow a (hsya) from flowers of carthamus tinctorius l. and its vasodilatation effects on pulmonary artery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268686/
https://www.ncbi.nlm.nih.gov/pubmed/23519263
http://dx.doi.org/10.3390/molecules171214918
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