A Facile One-Pot Process for the Formation of Hindered Tertiary Amines

A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones...

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Detalles Bibliográficos
Autores principales: Wang, Zhouyu, Pei, Dong, Zhang, Yu, Wang, Chao, Sun, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268708/
https://www.ncbi.nlm.nih.gov/pubmed/22555302
http://dx.doi.org/10.3390/molecules17055151
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author Wang, Zhouyu
Pei, Dong
Zhang, Yu
Wang, Chao
Sun, Jian
author_facet Wang, Zhouyu
Pei, Dong
Zhang, Yu
Wang, Chao
Sun, Jian
author_sort Wang, Zhouyu
collection PubMed
description A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step.
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spelling pubmed-62687082018-12-20 A Facile One-Pot Process for the Formation of Hindered Tertiary Amines Wang, Zhouyu Pei, Dong Zhang, Yu Wang, Chao Sun, Jian Molecules Communication A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step. MDPI 2012-05-03 /pmc/articles/PMC6268708/ /pubmed/22555302 http://dx.doi.org/10.3390/molecules17055151 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Wang, Zhouyu
Pei, Dong
Zhang, Yu
Wang, Chao
Sun, Jian
A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title_full A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title_fullStr A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title_full_unstemmed A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title_short A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
title_sort facile one-pot process for the formation of hindered tertiary amines
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268708/
https://www.ncbi.nlm.nih.gov/pubmed/22555302
http://dx.doi.org/10.3390/molecules17055151
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