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Mechanistic Study of the Spiroindolones: A New Class of Antimalarials

During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions...

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Detalles Bibliográficos
Autores principales:	Zou, Bin, Yap, Peiling, Sonntag, Louis-Sebastian, Leong, Seh Yong, Yeung, Bryan K. S., Keller, Thomas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268731/ https://www.ncbi.nlm.nih.gov/pubmed/22922283 http://dx.doi.org/10.3390/molecules170910131

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