Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedion...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Jing-Jing, Zhang, Ke-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268734/
https://www.ncbi.nlm.nih.gov/pubmed/22565483
http://dx.doi.org/10.3390/molecules17055339
_version_ 1783376354551529472
author Xia, Jing-Jing
Zhang, Ke-Hua
author_facet Xia, Jing-Jing
Zhang, Ke-Hua
author_sort Xia, Jing-Jing
collection PubMed
description Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
format Online
Article
Text
id pubmed-6268734
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62687342018-12-20 Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water Xia, Jing-Jing Zhang, Ke-Hua Molecules Communication Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields. MDPI 2012-05-07 /pmc/articles/PMC6268734/ /pubmed/22565483 http://dx.doi.org/10.3390/molecules17055339 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Xia, Jing-Jing
Zhang, Ke-Hua
Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_full Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_fullStr Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_full_unstemmed Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_short Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_sort synthesis of n-substituted acridinediones and polyhydroquinoline derivatives in refluxing water
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268734/
https://www.ncbi.nlm.nih.gov/pubmed/22565483
http://dx.doi.org/10.3390/molecules17055339
work_keys_str_mv AT xiajingjing synthesisofnsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater
AT zhangkehua synthesisofnsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater

Ejemplares similares