New Bioactive Alkyl Sulfates from Mediterranean Tunicates

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic...

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Detalles Bibliográficos
Autores principales: Imperatore, Concetta, Aiello, Anna, D’Aniello, Filomena, Luciano, Paolo, Vitalone, Rocco, Meli, Rosaria, Raso, Giuseppina Mattace, Menna, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268736/
https://www.ncbi.nlm.nih.gov/pubmed/23103530
http://dx.doi.org/10.3390/molecules171112642
Descripción
Sumario:Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.

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