New Bioactive Alkyl Sulfates from Mediterranean Tunicates

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic...

Descripción completa

Detalles Bibliográficos
Autores principales: Imperatore, Concetta, Aiello, Anna, D’Aniello, Filomena, Luciano, Paolo, Vitalone, Rocco, Meli, Rosaria, Raso, Giuseppina Mattace, Menna, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268736/
https://www.ncbi.nlm.nih.gov/pubmed/23103530
http://dx.doi.org/10.3390/molecules171112642
_version_ 1783376355008708608
author Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Luciano, Paolo
Vitalone, Rocco
Meli, Rosaria
Raso, Giuseppina Mattace
Menna, Marialuisa
author_facet Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Luciano, Paolo
Vitalone, Rocco
Meli, Rosaria
Raso, Giuseppina Mattace
Menna, Marialuisa
author_sort Imperatore, Concetta
collection PubMed
description Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
format Online
Article
Text
id pubmed-6268736
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62687362018-12-13 New Bioactive Alkyl Sulfates from Mediterranean Tunicates Imperatore, Concetta Aiello, Anna D’Aniello, Filomena Luciano, Paolo Vitalone, Rocco Meli, Rosaria Raso, Giuseppina Mattace Menna, Marialuisa Molecules Article Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1–5) including three new molecules 1–3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1–3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells. MDPI 2012-10-26 /pmc/articles/PMC6268736/ /pubmed/23103530 http://dx.doi.org/10.3390/molecules171112642 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Luciano, Paolo
Vitalone, Rocco
Meli, Rosaria
Raso, Giuseppina Mattace
Menna, Marialuisa
New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title_full New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title_fullStr New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title_full_unstemmed New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title_short New Bioactive Alkyl Sulfates from Mediterranean Tunicates
title_sort new bioactive alkyl sulfates from mediterranean tunicates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268736/
https://www.ncbi.nlm.nih.gov/pubmed/23103530
http://dx.doi.org/10.3390/molecules171112642
work_keys_str_mv AT imperatoreconcetta newbioactivealkylsulfatesfrommediterraneantunicates
AT aielloanna newbioactivealkylsulfatesfrommediterraneantunicates
AT daniellofilomena newbioactivealkylsulfatesfrommediterraneantunicates
AT lucianopaolo newbioactivealkylsulfatesfrommediterraneantunicates
AT vitalonerocco newbioactivealkylsulfatesfrommediterraneantunicates
AT melirosaria newbioactivealkylsulfatesfrommediterraneantunicates
AT rasogiuseppinamattace newbioactivealkylsulfatesfrommediterraneantunicates
AT mennamarialuisa newbioactivealkylsulfatesfrommediterraneantunicates

Ejemplares similares