A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, includ...

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Detalles Bibliográficos
Autores principales: Sun, Guangli, Zhang, Xiaopo, Xu, Xudong, Yang, Junshan, Zhong, Mingliang, Yuan, Jingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268741/
https://www.ncbi.nlm.nih.gov/pubmed/22334066
http://dx.doi.org/10.3390/molecules17021883
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author Sun, Guangli
Zhang, Xiaopo
Xu, Xudong
Yang, Junshan
Zhong, Mingliang
Yuan, Jingquan
author_facet Sun, Guangli
Zhang, Xiaopo
Xu, Xudong
Yang, Junshan
Zhong, Mingliang
Yuan, Jingquan
author_sort Sun, Guangli
collection PubMed
description On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL.
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spelling pubmed-62687412018-12-10 A New Triterpene From Uncaria macrophylla and Its Antitumor Activity Sun, Guangli Zhang, Xiaopo Xu, Xudong Yang, Junshan Zhong, Mingliang Yuan, Jingquan Molecules Article On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL. MDPI 2012-02-14 /pmc/articles/PMC6268741/ /pubmed/22334066 http://dx.doi.org/10.3390/molecules17021883 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sun, Guangli
Zhang, Xiaopo
Xu, Xudong
Yang, Junshan
Zhong, Mingliang
Yuan, Jingquan
A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title_full A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title_fullStr A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title_full_unstemmed A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title_short A New Triterpene From Uncaria macrophylla and Its Antitumor Activity
title_sort new triterpene from uncaria macrophylla and its antitumor activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268741/
https://www.ncbi.nlm.nih.gov/pubmed/22334066
http://dx.doi.org/10.3390/molecules17021883
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