Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes

An interagency collaboration was established to model chemical interactions that may cause adverse health effects when an exposure to a mixture of chemicals occurs. Many of these chemicals—drugs, pesticides, and environmental pollutant—interact at the level of metabolic biotransformations mediated b...

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Detalles Bibliográficos
Autores principales: McPhail, Brooks, Tie, Yunfeng, Hong, Huixiao, Pearce, Bruce A., Schnackenberg, Laura K., Ge, Weigong, Fuscoe, James C., Tong, Weida, Buzatu, Dan A., Wilkes, Jon G., Fowler, Bruce A., Demchuk, Eugene, Beger, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268752/
https://www.ncbi.nlm.nih.gov/pubmed/22421792
http://dx.doi.org/10.3390/molecules17033383

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