Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against eryth...

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Autores principales: Barea, Carlos, Pabón, Adriana, Galiano, Silvia, Pérez-Silanes, Silvia, Gonzalez, German, Deyssard, Chloe, Monge, Antonio, Deharo, Eric, Aldana, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268756/
https://www.ncbi.nlm.nih.gov/pubmed/22871647
http://dx.doi.org/10.3390/molecules17089451
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author Barea, Carlos
Pabón, Adriana
Galiano, Silvia
Pérez-Silanes, Silvia
Gonzalez, German
Deyssard, Chloe
Monge, Antonio
Deharo, Eric
Aldana, Ignacio
author_facet Barea, Carlos
Pabón, Adriana
Galiano, Silvia
Pérez-Silanes, Silvia
Gonzalez, German
Deyssard, Chloe
Monge, Antonio
Deharo, Eric
Aldana, Ignacio
author_sort Barea, Carlos
collection PubMed
description Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.
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spelling pubmed-62687562018-12-12 Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives Barea, Carlos Pabón, Adriana Galiano, Silvia Pérez-Silanes, Silvia Gonzalez, German Deyssard, Chloe Monge, Antonio Deharo, Eric Aldana, Ignacio Molecules Article Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties. MDPI 2012-08-07 /pmc/articles/PMC6268756/ /pubmed/22871647 http://dx.doi.org/10.3390/molecules17089451 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Barea, Carlos
Pabón, Adriana
Galiano, Silvia
Pérez-Silanes, Silvia
Gonzalez, German
Deyssard, Chloe
Monge, Antonio
Deharo, Eric
Aldana, Ignacio
Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title_full Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title_fullStr Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title_full_unstemmed Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title_short Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
title_sort antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268756/
https://www.ncbi.nlm.nih.gov/pubmed/22871647
http://dx.doi.org/10.3390/molecules17089451
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