Thiadiazines, N,N-Heterocycles of Biological Relevance

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-s...

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Detalles Bibliográficos
Autores principales: Rodríguez, Hortensia, Suárez, Margarita, Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268759/
https://www.ncbi.nlm.nih.gov/pubmed/22732878
http://dx.doi.org/10.3390/molecules17077612
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author Rodríguez, Hortensia
Suárez, Margarita
Albericio, Fernando
author_facet Rodríguez, Hortensia
Suárez, Margarita
Albericio, Fernando
author_sort Rodríguez, Hortensia
collection PubMed
description The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.
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spelling pubmed-62687592018-12-12 Thiadiazines, N,N-Heterocycles of Biological Relevance Rodríguez, Hortensia Suárez, Margarita Albericio, Fernando Molecules Review The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: Synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed. MDPI 2012-06-25 /pmc/articles/PMC6268759/ /pubmed/22732878 http://dx.doi.org/10.3390/molecules17077612 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Rodríguez, Hortensia
Suárez, Margarita
Albericio, Fernando
Thiadiazines, N,N-Heterocycles of Biological Relevance
title Thiadiazines, N,N-Heterocycles of Biological Relevance
title_full Thiadiazines, N,N-Heterocycles of Biological Relevance
title_fullStr Thiadiazines, N,N-Heterocycles of Biological Relevance
title_full_unstemmed Thiadiazines, N,N-Heterocycles of Biological Relevance
title_short Thiadiazines, N,N-Heterocycles of Biological Relevance
title_sort thiadiazines, n,n-heterocycles of biological relevance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268759/
https://www.ncbi.nlm.nih.gov/pubmed/22732878
http://dx.doi.org/10.3390/molecules17077612
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