Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri

Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone...

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Autores principales: Mah, Siau Hui, Ee, Gwendoline Cheng Lian, Teh, Soek Sin, Rahmani, Mawardi, Lim, Yang Mooi, Go, Rusea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268770/
https://www.ncbi.nlm.nih.gov/pubmed/22781442
http://dx.doi.org/10.3390/molecules17078303
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author Mah, Siau Hui
Ee, Gwendoline Cheng Lian
Teh, Soek Sin
Rahmani, Mawardi
Lim, Yang Mooi
Go, Rusea
author_facet Mah, Siau Hui
Ee, Gwendoline Cheng Lian
Teh, Soek Sin
Rahmani, Mawardi
Lim, Yang Mooi
Go, Rusea
author_sort Mah, Siau Hui
collection PubMed
description Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells.
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spelling pubmed-62687702018-12-12 Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri Mah, Siau Hui Ee, Gwendoline Cheng Lian Teh, Soek Sin Rahmani, Mawardi Lim, Yang Mooi Go, Rusea Molecules Article Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells. MDPI 2012-07-10 /pmc/articles/PMC6268770/ /pubmed/22781442 http://dx.doi.org/10.3390/molecules17078303 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mah, Siau Hui
Ee, Gwendoline Cheng Lian
Teh, Soek Sin
Rahmani, Mawardi
Lim, Yang Mooi
Go, Rusea
Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title_full Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title_fullStr Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title_full_unstemmed Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title_short Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
title_sort phylattrin, a new cytotoxic xanthone from calophyllum soulattri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268770/
https://www.ncbi.nlm.nih.gov/pubmed/22781442
http://dx.doi.org/10.3390/molecules17078303
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