Efficient Preparation of α-Ketoacetals

The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as...

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Detalles Bibliográficos
Autores principales: Ayala-Mata, Francisco, Barrera-Mendoza, Citlalli, Jiménez-Vázquez, Hugo A., Vargas-Díaz, Elena, Zepeda, L. Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268805/
https://www.ncbi.nlm.nih.gov/pubmed/23174902
http://dx.doi.org/10.3390/molecules171213864
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author Ayala-Mata, Francisco
Barrera-Mendoza, Citlalli
Jiménez-Vázquez, Hugo A.
Vargas-Díaz, Elena
Zepeda, L. Gerardo
author_facet Ayala-Mata, Francisco
Barrera-Mendoza, Citlalli
Jiménez-Vázquez, Hugo A.
Vargas-Díaz, Elena
Zepeda, L. Gerardo
author_sort Ayala-Mata, Francisco
collection PubMed
description The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
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spelling pubmed-62688052018-12-14 Efficient Preparation of α-Ketoacetals Ayala-Mata, Francisco Barrera-Mendoza, Citlalli Jiménez-Vázquez, Hugo A. Vargas-Díaz, Elena Zepeda, L. Gerardo Molecules Article The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol. MDPI 2012-11-22 /pmc/articles/PMC6268805/ /pubmed/23174902 http://dx.doi.org/10.3390/molecules171213864 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ayala-Mata, Francisco
Barrera-Mendoza, Citlalli
Jiménez-Vázquez, Hugo A.
Vargas-Díaz, Elena
Zepeda, L. Gerardo
Efficient Preparation of α-Ketoacetals
title Efficient Preparation of α-Ketoacetals
title_full Efficient Preparation of α-Ketoacetals
title_fullStr Efficient Preparation of α-Ketoacetals
title_full_unstemmed Efficient Preparation of α-Ketoacetals
title_short Efficient Preparation of α-Ketoacetals
title_sort efficient preparation of α-ketoacetals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268805/
https://www.ncbi.nlm.nih.gov/pubmed/23174902
http://dx.doi.org/10.3390/molecules171213864
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