Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and elemental...

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Detalles Bibliográficos
Autores principales: Tang, Zilong, Zhu, Zhonghua, Xia, Zanwen, Liu, Hanwen, Chen, Jinwen, Xiao, Wenjing, Ou, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268816/
https://www.ncbi.nlm.nih.gov/pubmed/22772812
http://dx.doi.org/10.3390/molecules17078174
Descripción
Sumario:A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.

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