Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and elemental...

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Detalles Bibliográficos
Autores principales: Tang, Zilong, Zhu, Zhonghua, Xia, Zanwen, Liu, Hanwen, Chen, Jinwen, Xiao, Wenjing, Ou, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268816/
https://www.ncbi.nlm.nih.gov/pubmed/22772812
http://dx.doi.org/10.3390/molecules17078174
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author Tang, Zilong
Zhu, Zhonghua
Xia, Zanwen
Liu, Hanwen
Chen, Jinwen
Xiao, Wenjing
Ou, Xiaoming
author_facet Tang, Zilong
Zhu, Zhonghua
Xia, Zanwen
Liu, Hanwen
Chen, Jinwen
Xiao, Wenjing
Ou, Xiaoming
author_sort Tang, Zilong
collection PubMed
description A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.
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spelling pubmed-62688162018-12-12 Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines Tang, Zilong Zhu, Zhonghua Xia, Zanwen Liu, Hanwen Chen, Jinwen Xiao, Wenjing Ou, Xiaoming Molecules Article A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani. MDPI 2012-07-06 /pmc/articles/PMC6268816/ /pubmed/22772812 http://dx.doi.org/10.3390/molecules17078174 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tang, Zilong
Zhu, Zhonghua
Xia, Zanwen
Liu, Hanwen
Chen, Jinwen
Xiao, Wenjing
Ou, Xiaoming
Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title_full Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title_fullStr Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title_full_unstemmed Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title_short Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines
title_sort synthesis and fungicidal activity of novel 2,3-disubstituted-1,3-benzoxazines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268816/
https://www.ncbi.nlm.nih.gov/pubmed/22772812
http://dx.doi.org/10.3390/molecules17078174
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AT liuhanwen synthesisandfungicidalactivityofnovel23disubstituted13benzoxazines
AT chenjinwen synthesisandfungicidalactivityofnovel23disubstituted13benzoxazines
AT xiaowenjing synthesisandfungicidalactivityofnovel23disubstituted13benzoxazines
AT ouxiaoming synthesisandfungicidalactivityofnovel23disubstituted13benzoxazines

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